Farms.com Home   News

Lactogenic Immunity and Vaccines for Porcine Epidemic Diarrhea Virus (PEDV): Historical And Current Concepts

Morbidity, mortality, and loss of productivity from enteric diseases in neonatal piglets cost swine producers millions of dollars annually. In 2013-2014, the porcine epidemic diarrhea virus (PEDV) outbreak led to $900 million to $1.8 billion in annual losses to US swine producers.

Passive lactogenic immunity remains the most promising and effective way to protect neonatal suckling piglets from enteric diseases like PEDV. Protecting suckling piglets through lactogenic immunity is dependent on trafficking of pathogen-specific IgA plasmablasts to the mammary gland and accumulation of secretory IgA (sIgA) antibodies in milk, defined as the gut-mammary-sIgA axis.

Due to an impermeable placenta, piglets are born agammaglobulinic, and are highly susceptible to a plethora of infectious agents. They rely solely on colostrum and milk antibodies for maternal lactogenic immunity. Previous advances in the development of live and attenuated vaccines for another devastating diarrheal virus of pigs, transmissible gastroenteritis virus (TGEV), provide insights into the mechanisms of maternal immunity and piglet protection.

In this chapter, we will review previous research on TGEV-induced lactogenic immunity to provide a historical perspective on current efforts for PEDV control and vaccines in the swine industry. Identifying factors that influence lactogenic immunity and the gut-mammary-sIgA axis may lead to improved vaccine regimens for PEDV and other enteric pathogens in gestating swine and improved overall herd immunity, swine health and industry productivity. 

Source: AASV


Trending Video

In Swine Versation: Levers, Boardroom, and Feed Talk with Trey Keller from AMVC

Video: In Swine Versation: Levers, Boardroom, and Feed Talk with Trey Keller from AMVC

Welcome to an insightful discussion on levers, boardroom dynamics, and feed strategies in the swine industry with Trey Keller, Managing Partner and Swine Nutritionist at AMVC Nutritional Services.

1. Industry Journey and Vision: Trey shares his industry journey, from humble beginnings to becoming the Managing Partner at AMVC. Exploring the evolution of his vision and how it aligns with the present.

2. AMVC's Success and Growth: AMVC's notable #10 ranking among major U.S. pork producers. Insight into AMVC's goals, culture, and potential for future growth.

3. Swine Nutrition Management: Discussing the levers swine nutritionists use to manage the financial aspect for pork producers. Exploration of AMVC's ecosystem for nutrition management and the challenges and successes encountered.

4. Influence in the Boardroom: Unveiling strategies to create influence at both boardroom and slat levels. Highlighting the crucial messages and Trey's vision for effective communication.

5. Sow Feeding Programs: Insights into the creation and implementation of successful sow feeding programs. Trey shares his methodology, lessons learned, and openness to innovation in line with new trends. Debunking myths about feed and the importance of having a checklist.

6. Collaboration for Industry Progress: Exploring the role of collaboration within the pork industry and the need for internal and external support to drive progress.

Join us for a deep dive into the swine industry's dynamics, challenges, and opportunities with Trey Keller.