An international team of researchers has unlocked a large-scale genomic analysis of Setaria or foxtail millet, an important cereal crop. The study, led by researchers at the Chinese Academy of Agricultural Sciences and including scientists at NYU, advances our understanding of the domestication and evolution of foxtail millet, as well as the genetic basis for important agricultural traits.
"Foxtail millet is considered to be the foundation for early Chinese civilization," said Michael Purugganan, the Silver Professor of Biology at NYU and NYU Abu Dhabi, and the study's co-senior author. "Moreover, because it is a crop that can grow across a wide range of environments—including arid lands—it has the potential to be important for food security under climate change."
Foxtail millet is one of the oldest domesticated grain crops in the world and has been grown by humans for roughly 11,000 years. It held a dominant position in Chinese agriculture before the introduction of high-input agricultural practices like irrigation and chemical fertilizers. The protein-rich grain—which employs C4 photosynthesis, a highly efficient form of photosynthesis that helps it adapt to different environments—is resilient to drought and able to thrive in low-nutrient soils.
"C4 plants constitute only about 3% of flowering plant species, but they surprisingly contribute to approximately 25-30% of global biomass production. The complexity of the genomes of most C4 species has posed challenges for fundamental studies and breeding, but Setaria serves as an ideal model system for studying C4 photosynthetic plants in genomics and genetics research," said Xianmin Diao, a professor in the Institute of Crop Sciences at the Chinese Academy of Agricultural Sciences, the study's co-senior author, and the scientist who organized the study.
In their study published in the journal Nature Genetics, the researchers established the Setaria pan-genome—the entire set of the species' genes—by assembling 110 representative genomes from a worldwide collection of 1,844 Setaria species. They performed large-scale genetic studies for 68 traits across 22 environments in 13 geographical locations, each with distinct climactic conditions, identifying potential genes and marker-panels for how foxtail millet has evolved and improved at different geographic sites. For instance, the researchers found that the gene SiGW3 regulates grain yield of foxtail millet.
They also constructed the first graph-based genome sequence of Setaria, offering insights into genomic variation across wild and cultivated Setaria. This deeper understanding of the comprehensive genomic variation equips researchers with valuable genetic tools to pursue biological research and breeding efforts.
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