Pig Gene Advance Could Boost Sperm Stocks From Prized Animals

Jan 16, 2017

Gene-editing techniques could help to improve stocks of farmed pigs by boosting supplies of sperm from prized sires.

Scientists have created male pigs that could be used as surrogates capable of producing sperm that contains the genetic blueprint of sought-after pigs.

The surrogates have functional testes but do not have specialised stem cells that are required to produce sperm containing their own genetic information, the researchers say.

Stem cells from male pigs with desirable characteristics - such as greater resilience to disease - could be transplanted into the surrogates to produce limitless supplies of their valuable sperm.

Previous efforts to preserve sperm stem cells from prized pigs by transplanting them into surrogate pigs have so far had limited success.

Existing methods involve using chemotherapy drugs or irradiation to remove sperm stem cells from the recipients before transplanting donor cells. These approaches can also damage other tissues in the testes that are needed for sperm production, however.

Researchers used a sophisticated genetic tool called CRISPR/Cas9 to alter individual letters of the pig's genetic code leading to inactivation of a gene called NANOS2.

The scientists found that pigs with two copies of the DNA change do not have sperm stem cells and cannot produce sperm, making them completely sterile.

All other aspects of testicular development were completely unaffected and the animals are otherwise healthy. Female pigs were also unaffected by the change to their genetic code.

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