AgriLabs® ENABL® Adjuvant Technology Receives U.S. Patent

May 10, 2017

AgriLabs® today announced it has received a U.S. patent for ENABL® adjuvant technology and its use as a delivery system for the DNA vaccines the company is developing. The patent covers a broad range of adjuvant compositions and methods for human and animal health.

“This is a major step in commercialization of our DNA vaccine platform for a number of animal species,” says Steve Schram, president and CEO of AgriLabs. “DNA vaccines offer tremendous promise in terms of efficacy, safety and convenience, and ENABL technology is unique in its ability to help realize that potential.”

The Promise of DNA Vaccines

According to Schram, DNA vaccines can be tools in the fight against important and emerging animal diseases – via rapid response that’s far faster than conventional vaccines. In addition, DNA vaccines are attractive in that they don’t expose the animals being treated to disease-producing organisms and there is no risk of a modified pathogen mutating back to a virulent form. The use of DNA vaccines also provides the ability to differentiate among infected and vaccinated animals (DIVA).

ENABL adjuvant technology helps realize that promise through more efficient delivery of DNA-based vaccines, which results in a higher absorption of antigen and greater immune response, according to Dr. Tim Miller, chief scientific officer of AgriLabs.

“ENABL adjuvants feature a lipid/polymer matrix that allows for more efficient delivery of both DNA and traditional vaccines to target cells,” Miller says. “This means we have an expandable platform that can address issues such as reduced number of doses for DNA vaccines, which makes them economically viable options. “

DNA vaccines being developed by AgriLabs will also provide ease of transport and storage since they are stable in refrigeration and at room temperature, according to Miller.

Opportunities across Species

Initially, AgriLabs is working to secure USDA approval for its DNA vaccine platform in poultry and swine. AgriLabs is developing vaccines based on the platform for those species, as well as cattle and other food animals in the United States. The company is seeking commercial partners to license the DNA vaccine platform for companion animal usage and food animals outside the United States.

“Our DNA platform, including ENABL adjuvant technology, represents the next generation of biological innovation in animal health,” Schram says. “We’re pleased to be recognized with the granting of a patent for this significant step forward.”

Source:agrilabs.com

Video: WARNING! Rough Start To Breeding Season!!

WARNING! Sheep Breeding Season Begins With A Bang! Breeding season is officially underway at Ewetopia Farms, but it didn’t exactly start the way we planned!

This vlog begins with us sorting through our rams to find the perfect match for a customer’s breeding program. What should have been routine quickly turned dangerous when one of our more nervous rams panicked. In seconds, Arnie’s knee was injured, and then I was slammed hard onto the concrete floor — both of us taken down by one ram!

Thankfully, it was just bruises, but it’s a reminder of how unpredictable and powerful mature rams can be. Once we recovered, it was time to get back to the real work — the start of breeding season.

We sorted the ewes into four breeding groups (two Suffolk and two Dorset), checking parentage as they ran through the chute, deworming those that needed it, and setting aside thinner ewes for session two of breeding season in a month’s time.This staggered approach keeps lambing organized and prevents overcrowding in the barns.

From rogue rams to the excitement of new breeding groups, this episode is full of action. Stay tuned for the next vlog, where we’ll share how we chose the rams for each group!