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New studies aim to solve cattle liver abscess mystery

By Farms.com

Liver abscesses represent a critical issue in cattle farming, affecting both the well-being of animals and the financial health of industry. In an unprecedented collaborative effort, scientists from the USDA and various universities are delving into the causes and development of liver abscesses in cattle. Their research aims to create effective models to study this condition, shedding light on how to prevent it. 

A notable achievement of this collaboration is the establishment of a liver abscess model that demonstrates a consistent 50% prevalence rate. The research primarily focuses on the dietary causes and bacterial involvement in liver abscess formation. High-grain diets have been identified as a possible risk factor due to their impact on rumen pH levels, potentially facilitating bacterial infections that lead to abscesses. 

The findings have also introduced the possibility that the primary bacteria involved in these abscesses might come from parts of the gastrointestinal tract other than the rumen, challenging previous assumptions and indicating new directions for prevention and treatment. 

This quest for knowledge extends beyond the academic realm, aiming to replace antibiotic treatments with more sustainable solutions, such as adjustments in nutritional management. Such advancements could lead to significant improvements in cattle health and welfare, while also addressing public concerns over antibiotic resistance. 

This groundbreaking research underscores the importance of scientific collaboration in addressing complex agricultural challenges. By understanding the intricacies of liver abscesses in cattle, the agricultural community hopes to develop innovative, effective strategies for prevention and treatment, ensuring the sustainability and profitability of cattle farming.


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In this episode of The Swine it Podcast Show Canada, Dr. Jishu Shi, Professor of Vaccine Immunology at Kansas State University, discusses African swine fever prevention and vaccine development. He explains why ASF differs from classical swine fever and swine influenza, how the disease threatens trade and pork production, why immunization safety remains a critical hurdle, and what producers can do now to reduce the risk of introduction. Listen now on all major platforms!

"Before a safe and efficacious vaccine for ASF can be commercialized, what we really have is prevention."

Meet the guest: Dr. Jishu Shi is Professor of Vaccine Immunology and the Dr. Wayne & Hilda Appleton Endowed Professor at Kansas State University’s College of Veterinary Medicine. He directs the Center on Biologics Development and Evaluation and the U.S.-China Center for Animal Health. A veterinarian and vaccine immunologist, Dr. Shi has focused on vaccines for pigs and has worked on African swine fever vaccine development, control, diagnostics, and international training since 2018. Learn more from Dr. Jishu Shi on The Swine it Podcast Show Canada, available on all major platforms.