Abstract: Vaccination Decreases the Risk of Influenza A Virus Reassortment but not Genetic Variation in Pigs

Sep 26, 2022

Abstract: Vaccination decreases the risk of influenza A virus reassortment but not genetic variation in pigs

Although vaccination is broadly used in North American swine breeding herds, managing swine influenza is challenging primarily due to the continuous evolution of influenza A virus (IAV) and the ability of the virus to transmit among vaccinated pigs. Studies that have simultaneously assessed the impact of vaccination on the emergence of IAV reassortment and genetic variation in pigs are limited. Here, we directly sequenced 28 bronchoalveolar lavage fluid (BALF) samples collected from vaccinated and unvaccinated pigs co-infected with H1N1 and H3N2 IAV strains, and characterized 202 individual viral plaques recovered from 13 BALF samples. We identified 54 reassortant viruses that were grouped in 17 single and 16 mixed genotypes. Notably, we found that prime-boost vaccinated pigs had less reassortant viruses than nonvaccinated pigs, likely due to a reduction in the number of days pigs were co-infected with both challenge viruses.

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Video: Farm Health Guardian | Digital Biosecurity in Real Time

Disease risk, biosecurity, and real-time monitoring continue to be major topics across the pork industry. In this episode of Swine Web Industry Perspectives, presented by Farm Health Guardian, we discuss how digital biosecurity and real-time data are changing the way producers think about herd protection, people movement, and operational decision-making.

The conversation explores:

disease risk in modern pork production,

the impact of people movement on biosecurity,

the importance of real-time monitoring,

digital biosecurity technology,

and how Farm Health Guardian developed tools designed to support modern swine operations.

As the industry continues focusing on prevention, preparedness, and operational efficiency, connected technologies and actionable data are becoming increasingly important parts of modern herd health management.