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Help Piglets Thrive: High-Dose Oxytocin Allows Sows to Pass on Greater Immunity

Colostrum can be the difference between life and death for a piglet. As litter size increases, colostrum intake becomes even more critical, says Bryn Anderson, a veterinary student at the University of Minnesota College of Veterinary Medicine.

“Passive transfer of immunity is one of the most critical determinants of piglet survival and early growth, yet it remains highly variable in commercial systems,” she explained at the Allen D. Leman Swine Conference. “Piglets rely entirely on colostrum for immunoglobulins, but successful intake depends on factors like sow physiology, litter size and piglet vigor.”

She says this variability means that a proportion of piglets consistently fall short of adequate immune protection.

“There has been growing interest in whether management interventions—such as administering oxytocin—could stimulate more efficient colostrum release in the immediate postpartum period,” Anderson says.

She set out to evaluate whether giving a higher dose of oxytocin would improve both colostrum quality and piglet immunoglobulin transfer, since even modest improvements could have meaningful impacts to any size of pork production.

Does Oxytocin Help?
In a systematic, controlled field trial at a commercial sow farm, Anderson enrolled 96 sows in her study and randomly assigned them to either receive a high dose of oxytocin 12–20 hours after farrowing or serve as untreated controls.

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In this episode of The Swine it Podcast Show Canada, Dr. Mary-Louise Penrith, Extraordinary Professor at the University of Pretoria, shares what decades of work have revealed about ASF control. She explains why vaccine development remains difficult, how human activity and food waste drive disease spread, why resistant pig populations are an important research area, and how strict biosecurity with the right disinfectants can help to stop transmission. Listen now on all major platforms!

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Meet the guest: Dr. Mary-Louise Penrith / mary-louise-penrith-2b12bb42 is an Extraordinary Professor in the Department of Veterinary Tropical Diseases at the University of Pretoria, South Africa. A veterinarian and internationally recognized researcher, she has dedicated decades to African swine fever epidemiology, control, and pig health, supporting FAO and WOAH initiatives while advancing research and education. Listen to Dr. Mary-Louise Penrith on the Swine Health Blackbelt Podcast, available on all major platforms.