Prevention and Control of Porcine Epidemic Diarrhea: The Development of Recombination-Resistant Live Attenuated Vaccines

Jul 29, 2022

Abstract: Prevention and Control of Porcine Epidemic Diarrhea: The Development of Recombination-Resistant Live Attenuated Vaccines

Porcine epidemic diarrhea (PED), causing up to 100% mortality in neonatal pigs, is a highly contagious enteric disease caused by PED virus (PEDV). The highly virulent genogroup 2 (G2) PEDV emerged in 2010 and has caused huge economic losses to the pork industry globally. It was first reported in the US in 2013, caused country-wide outbreaks, and posed tremendous hardship for many pork producers in 2013-2014. Vaccination of pregnant sows/gilts with live attenuated vaccines (LAVs) is the most effective strategy to induce lactogenic immunity in the sows/gilts and provide a passive protection via the colostrum and milk to suckling piglets against PED. However, there are still no safe and effective vaccines available after about one decade of endeavor. One of the biggest concerns is the potential reversion to virulence of an LAV in the field. In this review, we summarize the status and the major obstacles in PEDV LAV development. We also discuss the function of the transcriptional regulatory sequences in PEDV transcription, contributing to recombination, and possible strategies to prevent the reversion of LAVs. This article provides insights into the rational design of a promising LAV without safety issues.

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Video: Synthetic Microbiota Explained - Dr. Alexandre Thibodeau

In this episode of The Swine it Podcast Show Canada, Dr. Alexandre Thibodeau, from the University of Montreal, explains how synthetic microbiota and bioreactor systems can help researchers study gut microorganisms, evaluate feed additives, investigate Salmonella control strategies, and develop alternatives to animal trials. Listen now on all major platforms!

"Bioreactor models can screen microbiota solutions before animal trials, lowering costs and reducing the number of pigs needed."

Meet the guest: Dr. Alexandre Thibodeau / alexandre-thibodeau-2493a540 is an Associate Professor at the University of Montreal, in Canada, with a PhD in Veterinary Science and Microbiology. His work focuses on swine gut health, food safety, microbiota research, pathogen control, and alternative research models that support animal production and welfare. His research explores innovative strategies to better understand interactions among microorganisms and to improve livestock health outcomes. Learn more from Dr. Alexandre Thibodeau on The Swine it Podcast Show Canada, available on all major platforms.