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The Path to a PRRS-Resistant Pig: A Look at What’s Next

Where is the pork industry on its path to a PRRS-resistant pig? Matt Culbertson, chief operating officer at PIC, says the industry is entering the final chapter of the story before the opportunity to commercialize pig genetics that are resistant to porcine reproductive and respiratory syndrome (PRRS). These pigs were developed utilizing non-transgenic gene editing to inactivate a specific gene, CD163, that exists in the pig and allows PRRS infection to occur.  

“We are at the point of finalizing regulatory approval activities in multiple geographies around the globe that should allow the necessary framework for not only production in many key pork producing countries, like the U.S., but also for uninterrupted global movement of pork products,” Culbertson said during a presentation at the Carthage Swine Conference. 

PIC is scaling up its own internal production of the PRRS-resistant populations to be ready for the potential launch.

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Intrauterine Vaccines in Swine - Dr. Heather Wilson

Video: Intrauterine Vaccines in Swine - Dr. Heather Wilson



In this episode of The Swine it Podcast Show Canada, Dr. Heather Wilson from VIDO at the University of Saskatchewan explains how intrauterine vaccination is being developed as a new option for swine health. She shares how formulation, adjuvants, and delivery methods influence immune responses and what early trials reveal about safety and reproductive performance. Listen now on all major platforms.

"The idea was that an intrauterine vaccine might avoid a tolerance response and instead create an active immune response."

Meet the guest: Dr. Heather Wilson / heather-wilson-a8043641 is a Senior Scientist and Program Manager at the Vaccine and Infectious Disease Organization at the University of Saskatchewan. Her work centers on vaccine formulation and delivery in pigs, including the development of intrauterine vaccination to support reproductive health and passive protection of piglets. Her background spans biochemistry, immunology, and functional pathogenomics.