Farms.com Home   News

Doctors Transplant A Genetically Modified Pig Heart Into A Human For The 1st Time

Doctors Transplant A Genetically Modified Pig Heart Into A Human For The 1st Time

In a medical first, doctors transplanted a pig heart into a patient in a last-ditch effort to save his life and a Maryland hospital said Monday that he's doing well three days after the highly experimental surgery.

While it's too soon to know if the operation really will work, it marks a step in the decades-long quest to one day use animal organs for life-saving transplants. Doctors at the University of Maryland Medical Center say the transplant showed that a heart from a genetically modified animal can function in the human body without immediate rejection.

The patient, David Bennett, 57, knew there was no guarantee the experiment would work but he was dying, ineligible for a human heart transplant and had no other option, his son told The Associated Press.

"It was either die or do this transplant. I want to live. I know it's a shot in the dark, but it's my last choice," Bennett said a day before the surgery, according to a statement provided by the University of Maryland School of Medicine.

There's a huge shortage of human organs donated for transplant, driving scientists to try to figure out how to use animal organs instead. Last year, there were just over 3,800 heart transplants in the U.S., a record number, according to the United Network for Organ Sharing, which oversees the nation's transplant system.

"If this works, there will be an endless supply of these organs for patients who are suffering," said Dr. Muhammad Mohiuddin, scientific director of the university's animal-to-human transplant program.

But prior attempts at such transplants — or xenotransplantation — have failed, largely because patients' bodies rapidly rejected the animal organ. Notably, in 1984, Baby Fae, a dying infant, lived 21 days with a baboon heart.

The difference this time: The Maryland surgeons used a heart from a pig that had undergone gene-editing to remove a sugar in its cells that's responsible for that hyper-fast organ rejection.

"I think you can characterize it as a watershed event," Dr. David Klassen, UNOS' chief medical officer, said of the Maryland transplant.

Still, Klassen cautioned that it's only a first tentative step into exploring whether this time around, xenotransplantation might finally work.

The Food and Drug Administration, which oversees xenotransplantation experiments, allowed the surgery under what's called a "compassionate use" emergency authorization, available when a patient with a life-threatening condition has no other options.

Click here to see more...

Trending Video

Season 6, Episode 3: Manure Handling Connections Between PRRSV and PEDV

Video: Season 6, Episode 3: Manure Handling Connections Between PRRSV and PEDV

Biosecurity is vital to any swine operation, and manure handling can pose serious potential risks. Research from Ana Paula Serafini Poeta Silva, a research scientist from the College of Veterinary Medicine at Iowa State University, studied the association between manure management practices and disease outbreaks, Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) and Porcine Epidemic Diarrhea Virus (PEDV). On today’s episode, she highlights the analysis on improving pumping procedures and which disease showed a stronger association in wean-to-market pigs