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How Can Nutrition Prevent E. coli in Weaned Pigs?

Post-weaning diarrhea (PWD) is generally defined as loose, watery stool occurring in the first 14 days after weaning. The incidence of PWD is multi-faceted, but often results from exposure to infectious pathogens such as rotavirus, Salmonella or Escherichia coli (E. coli). Sensitivity to PWD is also affected by physiological and metabolic changes of the gastrointestinal (GI) system that occur at the time of weaning, leaving the newly weaned pig more vulnerable to enteric disease outbreaks. Here are four ways nutrition can help.

DIETARY ZINC AND COPPER
To prevent pathogen induced diarrhea in weanling pigs, pharmacological levels of zinc (2,000 to 3,000 ppm) from zinc oxide (ZnO) are commonly fed for the first 2 to 3 weeks after weaning. The mode of action of ZnO is not well understood; however, several different mechanisms related to immune system modulation, nutrient absorption and preservation of intestinal morphology have been identified. Copper is another mineral that can be fed to prevent pathogen induced diarrhea. However, pharmacological levels of copper (125 to 250 ppm) from copper sulfate or tribasic copper chloride generally aren’t fed until late nursery. Unfortunately, these feeding practices have led to increased environmental concerns and issues surrounding bacterial resistance. This emphasizes the need to evaluate alternative feeding strategies for the prevention and management of enteric disease, specifically E. coli.

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Nutrition and Sow Livability - Dr. Mark Knauer

Video: Nutrition and Sow Livability - Dr. Mark Knauer


In this episode of The Swine it Podcast Show, Dr. Mark Knauer, Swine Extension Specialist at North Carolina State University, discusses nutritional strategies to improve sow livability and piglet outcomes. He shares research insights on vitamin programs, antioxidant support, and nutrition-based approaches in commercial production systems. Dr. Knauer highlights opportunities to reduce mortality, enhance sow longevity, and improve overall performance. Listen now on all major platforms!

“Disease challenges create oxidative stress, and replenishing antioxidants can help to support sow and piglet livability.”

Meet the guest: Dr. Mark Knauer / mark-knauer-0475b921 is a Swine Extension Specialist at North Carolina State University, where he conducts applied research to improve sow productivity, longevity, and herd performance. He earned his Ph.D. from North Carolina State University and previously served as Director of Animal Science at the National Pork Board. Learn more from Dr. Mark Knauer on The Swine it Podcast Show, available on all major platforms.