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Complexity of Virus Makes Developing ASF Vaccines Challenging

The Associate Director Research with VIDO-InterVac says the complexity of the virus responsible for African Swine Fever has made the development of a vaccine to prevent it extremely challenging.

Since receiving federal approval about a year and a half ago to work with African Swine Fever the Vaccine and Infectious Disease Organization has been working on two approaches for preventing the disease, the development of a viral vectored vaccine using an adenovirus to deliver one or more of the genes from ASF to the pig to stimulate immunity and the identification of compounds that would prevent viral replication within cells and protect pigs in much the same way as a vaccine.

Dr. Andrew Van Kessel, the Associate Director Research with VIDO-InterVac, says this infection is not only a serious risk to animal health but it also carries significant trade implications.

Clip-Dr. Andrew Van Kessel-VIDO-InterVac:

It's a viral infection of pigs that is relatively slowly transmitted but is highly devastating in terms of its impact on mortality. It's nearly 100 percent fatal in terms of the infection.

Of course, there's a concern in terms of the impact of this disease as it transmits through the herd in terms of the performance and health of animals but, as we are well aware in Canada, this is an OIE reportable disease.

The disease is not present in North America at present. Should it arrive in Canada the impact would be devastating primarily from a closure of borders to international trade and the implications that has given that in Canada we sell two of every three hogs at least on an international market and the impact that would have on the swine business would certainly be devastating.

Source : Farmscape

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Porcine Gut Models in Nutrition Research - Dr. Li-Hsuan Chen

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In this episode of The Swine Nutrition Blackbelt Podcast, Dr. Li-Hsuan Chen, postdoc researcher at Aarhus University, discusses how porcine intestinal cell lines and organoids can help study the impact of nutrition on gut health. He explains how in vivo piglet trials identify diet-driven shifts in microbiota and metabolites, while in vitro models allow researchers to test specific metabolites, barrier function, immune markers, and future organ-on-chip systems before moving back to animal studies. Listen now on all major platforms!

"In vitro models can reduce early animal use by helping researchers screen nutritional candidates before moving back to in vivo trials."

Meet the guest: Dr. Li-Hsuan Chen / li-hsuan-chen-9a95a7279 is a postdoc researcher at Aarhus University in Denmark. Research focuses on porcine gut health, host-microbe interactions, cell lines, and organoids, with PhD work at Aarhus University studying how dietary protein and amino acid levels shape gut microbiota, microbial metabolites, and intestinal epithelial responses. Learn more from Dr. Li-Hsuan Chen on The Swine Nutrition Blackbelt Podcast, available on all major platforms.