USDA Develops Candidate African Swine Fever Vaccine

Jun 10, 2021

By Greg Cima

A federal research team reported progress toward creating a commercial vaccine against the devastating African swine fever virus.

An article published in May in the Journal of Virology indicates Department of Agriculture scientists at the Plum Island Animal Disease Center in New York created an attenuated vaccine candidate that can reproduce in a continuous cell line, overcoming a limitation that previous vaccine candidates required fresh macrophages from live swine. USDA Agricultural Research Service scientists had developed a previous vaccine candidate that offered effective protection, but the macrophage requirements prevented large-scale production.

Two of the article authors—USDA ARS research microbiologists Manuel Borca, PhD, and Douglas Gladue, PhD—said in a joint message that the ASF virus requires primary swine macrophages to replicate, and those macrophages do not divide. The researchers adapted an ASF virus to reproduce in a cell line that was developed at the ARS from primary porcine epithelial cells, and the attenuated vaccine candidate they produced with that modified virus protected swine as well as their previous vaccine candidate.

Click here to see more...

Video: PRRS Eradication Strategies - Dr. DeBuse and Dr. Tousignant

In this episode of The Swine it Podcast Show, Dr. Neil DeBuse from Kalmbach Feeds and Dr. Steve Tousignant from Vaxxinova US discuss PRRS management strategies, recombination risks, whole genome sequencing, and the role of autogenous immunization programs in swine systems. They highlight practical approaches to improving immunity, reducing outbreaks, and advancing PRRS control across production systems. Listen now on all major platforms!

"Being PRRS negative sooner is a real key for eradication because every additional positive week increases production losses and viral exposure risks." - Dr. Neil DeBuse

Meet the guest: Dr. Neil DeBuse is a veterinarian at Kalmbach Feeds with more than 30 years of experience in swine health and production. His work focuses on PRRS control, biosecurity, immunity, and improving production stability across commercial swine systems in the United States and internationally.

Dr. Steve Tousignant is Director of the Swine Business Unit and Technical Services Veterinarian at Vaxxinova US, with a DVM and PhD from the University of Minnesota. His experience combines epidemiology, technical services, and practical immunization strategies designed to support consistent herd performance and long-term production stability. Don’t miss the chance to be part of the Swine Inner Circle!