Transmission Of Antibiotic Resistance At The Wildlife-Livestock Interface

Jul 28, 2022

Abstract: Transmission of antibiotic resistance at the wildlife-livestock interface

Antibiotic-resistant microorganisms (ARMs) are widespread in natural environments, animals (wildlife and livestock), and humans, which has reduced our capacity to control life threatening infectious disease. Yet, little is known about their transmission pathways, especially at the wildlife-livestock interface. This study investigated the potential transmission of ARMs and antibiotic resistance genes (ARGs) between cattle and wildlife by comparing gut microbiota and ARG profiles of feral swine (Sus scrofa), coyotes (Canis latrans), cattle (Bos taurus), and environmental microbiota. Unexpectedly, wild animals harbored more abundant ARMs and ARGs compared to grazing cattle. Gut microbiota of cattle was significantly more similar to that of feral swine captured within the cattle grazing area where the home range of both species overlapped substantially. In addition, ARMs against medically important antibiotics were more prevalent in wildlife than grazing cattle, suggesting that wildlife could be a source of ARMs colonization in livestock.

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Video: ASF Control Lessons - Dr. Mary-Louise Penrith

In this episode of The Swine it Podcast Show Canada, Dr. Mary-Louise Penrith, Extraordinary Professor at the University of Pretoria, shares what decades of work have revealed about ASF control. She explains why vaccine development remains difficult, how human activity and food waste drive disease spread, why resistant pig populations are an important research area, and how strict biosecurity with the right disinfectants can help to stop transmission. Listen now on all major platforms!

"It's really a very human-driven disease because people move pigs, decide how they're raised, how they're sold, and good biosecurity can do anything to ensure control."

Meet the guest: Dr. Mary-Louise Penrith / mary-louise-penrith-2b12bb42 is an Extraordinary Professor in the Department of Veterinary Tropical Diseases at the University of Pretoria, South Africa. A veterinarian and internationally recognized researcher, she has dedicated decades to African swine fever epidemiology, control, and pig health, supporting FAO and WOAH initiatives while advancing research and education. Listen to Dr. Mary-Louise Penrith on the Swine Health Blackbelt Podcast, available on all major platforms.